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Risk factors for venous thromboembolism
1Division of Cardiovascular Diseases, Section of Vascular Diseases, Division of Hematology, Section of Hematology Research, Stabile 610, Department of Internal Medicine, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA.
Clinics in Chest Medicine
|April 11, 2003
Summary
Venous thromboembolism (VTE) is a serious condition, particularly pulmonary embolism, which can cause sudden death. Reducing VTE incidence requires better risk identification and targeted prophylaxis.
Area of Science:
- Medical Science
- Epidemiology
- Public Health
Background:
- Venous thromboembolism (VTE) is a prevalent and life-threatening condition.
- Pulmonary embolism (PE) poses a significant risk of mortality, often independent of comorbidities.
- Sudden death can be the initial presentation of PE.
Purpose of the Study:
- To highlight the persistent incidence of VTE since 1980.
- To emphasize the need for improved VTE risk assessment and management strategies.
- To explore the potential of understanding VTE as a multifactorial disease for better risk identification.
Main Methods:
- Review of epidemiological data on VTE incidence.
- Analysis of risk factors and mortality associated with PE.
- Exploration of genetic and environmental interactions in VTE pathogenesis.
Main Results:
- VTE incidence has remained stable since the 1980s.
- PE-related deaths are often sudden and not solely attributable to other health issues.
- VTE is increasingly recognized as a complex disease influenced by genetics and environment.
Conclusions:
- Reducing VTE-related mortality necessitates a decrease in VTE incidence.
- Effective VTE prevention strategies include risk recognition, prophylaxis, and targeted interventions.
- Understanding the multifactorial nature of VTE offers new avenues for identifying at-risk individuals.