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Clinical and laboratory evaluation of thrombophilia
Stephanie L Perry1, Thomas L Ortel
1Division of Medical Oncology, Division of Hematology, Duke University Medical Center, Trent Drive, Durham, NC 27710, USA.
Clinics in Chest Medicine
|April 11, 2003
Abstract:
Thrombophilia is the predisposition to venous thromboembolism and is caused by inherited and acquired factors, alone or in combination. With the discovery of APC resistance and the prothrombin gene mutation, more than half of all patients with clinical characteristics of thrombophilia are now diagnosed with an inherited disorder. The hypercoagulable work-up of patients with venous thromboembolism is important, because the causes can influence the duration and management of anticoagulation therapy, as well as affect other decisions regarding life and health issues.