Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Causes of biliary sludge].

S Iu Sil'verstova, A A Il'chenko, V N Drozdov

    Terapevticheskii Arkhiv
    |April 11, 2003
    PubMed
    Summary

    Biliary sludge can form due to high cholesterol, low phospholipids, or normal bile composition. This study identifies three biochemical profiles associated with gallbladder sludge formation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea and antibiotic-associated diarrhea].

    Voprosy pitaniia·2023
    Same author

    [The results of the use of a combined probiotic (<i>Lactobacillus rhamnosus GG</i> and <i>Bifidobacterium animalis</i> spp. <i>lactis</i> ВB-12) in children with gastrointestinal and skin manifestations of food allergy].

    Voprosy pitaniia·2023
    Same author

    [Effect of 6-month S-methylmethionine intake on the quality of life and dyspepsia symptoms in patients with chronic gastritis].

    Voprosy pitaniia·2023
    Same author

    [The effectiveness of BIFIFORM KIDS in the prevention of the incidence of acute respiratory infections in children].

    Voprosy pitaniia·2022
    Same author

    [Alflutop - in modern symptom - modifying osteoarthritis therapy].

    Terapevticheskii arkhiv·2020
    Same author

    [Clinical efficacy of probiotic strains of the <i>Bifidobacterium</i> and <i>Lactobacillus</i>].

    Voprosy pitaniia·2020

    Area of Science:

    • Gastroenterology and Hepatology
    • Biochemistry
    • Lipid Metabolism

    Context:

    • Gallbladder sludge is a precursor to gallstones.
    • Understanding the biochemical basis of sludge formation is crucial for prevention and treatment.
    • Previous studies have focused on gallstones, but sludge composition requires specific investigation.

    Purpose:

    • To identify specific biochemical characteristics of bile that destabilize its colloidal properties, leading to biliary sludge.
    • To correlate bile composition with blood lipid profiles in patients with gallbladder sludge.

    Summary:

    • This study analyzed bile and blood lipid composition in 37 patients with gallbladder sludge, 10 with gallstones, and 10 controls.
    • Three distinct biochemical profiles of biliary sludge were identified: high cholesterol/phospholipids with low bile acids; normal cholesterol/bile acids with low phospholipids; and normal proportions of all three.
    • Elevated blood cholesterol and LDL-P were noted in the first group, while low HDL-P and triglycerides characterized the second.

    Impact:

    • Provides novel insights into the heterogeneous biochemical nature of biliary sludge.
    • Suggests that biliary sludge can arise from various compositional imbalances, not solely from supersaturation.
    • Highlights the potential role of altered lipid metabolism in sludge pathogenesis, informing future therapeutic strategies.

    Related Experiment Videos