Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A simulation study of methods for constructing confidence intervals for bioaccumulation factors.

Matthew W Wheeler1, A John Bailer

  • 1Center for Environmental Toxicology and Statistics, Department of Mathematics and Statistics, Miami University, Oxford, Ohio 45056, USA.

Environmental Toxicology and Chemistry
|April 11, 2003
PubMed
Summary

This study compares two methods for calculating bioaccumulation factors (BAFs) in toxicokinetics. The delta method is preferred for specific sampling times, while Fieller

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A hierarchical constrained density regression model for predicting cluster-level dose-response.

Environmetrics·2025
Same author

Extracellular Vesicle (EV) Mechanisms of Toxicity for Per and Polyfluoroalkyl Substances: Comparing Transcriptomic Points of Departure Across Global Versus EV Regulatory Gene Sets.

Environmental and molecular mutagenesis·2025
Same author

Bayesian gene set benchmark dose estimation for "omic" responses.

Bioinformatics (Oxford, England)·2025
Same author

The 2022 world health organization reevaluation of human and mammalian toxic equivalency factors for polychlorinated dioxins, dibenzofurans and biphenyls.

Regulatory toxicology and pharmacology : RTP·2023
Same author

Visualizing the NIOSH Pocket Guide: Open-source web application for accessing and exploring the NIOSH Pocket Guide to Chemical Hazards.

Journal of occupational and environmental hygiene·2023
Same author

A multi-tiered hierarchical Bayesian approach to derive toxic equivalency factors for dioxin-like compounds.

Regulatory toxicology and pharmacology : RTP·2023

Area of Science:

  • Environmental toxicology
  • Pharmacokinetics
  • Statistical modeling

Background:

  • Toxicokinetics studies the fate of xenobiotics in organisms.
  • Bioaccumulation factors (BAFs) quantify chemical accumulation.
  • Estimating BAFs involves continuous or start-stop exposure experiments.

Purpose of the Study:

  • To compare the performance of the delta method and Fieller's method for BAF confidence intervals.
  • To evaluate coverage properties and interval widths of CI methods under various conditions.
  • To determine optimal CI methods based on experimental design and sampling times.

Main Methods:

  • Simulation study to assess confidence interval (CI) methods.
  • Analysis of coverage probabilities and interval widths.

Related Experiment Videos

  • Comparison of delta method and Fieller's method for BAF estimation.

    • Main Results:

    • Fieller's method consistently exceeded nominal coverage probabilities.
    • The delta method showed lower-than-nominal coverage in some conditions.
    • Delta method provided narrower intervals with nominal coverage when sampling occurred before steady state or stop exposure.

    Conclusions:

    • The delta method is recommended for specific sampling designs (early sampling).
    • Fieller's method is advised for all other experimental conditions.
    • Method selection impacts the reliability of BAF estimation and toxicokinetic analysis.