CD Antigens: Review of Data Obtained by April' 98

Area of Science:

• Immunology
• Cell Biology
• Biochemistry

Background:

• Cluster of Differentiation (CD) nomenclature provides a chronological list of elucidated molecules, reflecting advances in immunology.
• The Subcommittee on CD Nomenclature, under the World Health Organization (WHO) and International Union of Immunological Societies (IUIS), manages this classification.
• CD molecule registration occurs at International Workshops on Human Differentiation Antigens, with the last held in 1996.

Purpose of the Study:

• To provide a comprehensive characterization of all elucidated CD molecules.
• To present this information in a multicomponent table format.
• To offer commentary on the structure and function of major CD molecule families and domains.

Main Methods:

• Compilation of data from the 6th International Workshop on Human Differentiation Antigens (1996).
• Inclusion of literature data from the 1997-1998 period.
• Creation of a multicomponent table summarizing CD molecule information.

Main Results:

• A table detailing elucidated CD molecules, updated with recent literature.
• Characterization of CD molecules based on their discovery timeline and immunological significance.
• Analysis of the structural and functional attributes of major CD molecule families and domains.

Conclusions:

• The CD nomenclature system serves as a vital tool for tracking immunological discoveries.
• This review consolidates current knowledge on CD molecules, aiding researchers.
• Understanding CD molecule families and domains is crucial for interpreting their roles in cell biology.