Influence of Immunology Advances on the Conjuncture and Evolution of Infectious Diseases

Anatoly A. Vorobyev1

  • 1I.M. Sechenov Moscow Medical Academy, Moscow, Russia.

Russian Journal of Immunology : RJI : Official Journal of Russian Society of Immunology
|April 11, 2003
PubMed

The main purpose of immunology in the field of infectious pathology is to artificially create collective insusceptibility of people to pathogens of infectious diseases. As immunology, knowledge of humoral and cellular mechanisms of protection, conditions affecting the effectiveness of the functioning and control of the immune system when exogenous and endogenous antigen substances act thereon developed, vaccinology and then immunobiotechnology also developed, i.e. those branches of immunology which are occupied with the development of measures and methods for specific prophylaxis of infectious and non-infectious diseases, methods of constructing and producing immunobiological preparations, their practical use in the prophylaxis and treatment of infectious and non-infectious diseases. Vaccinoprophylaxis is one of the most effective and economical methods for protection against infectious diseases. It should especially be underlined that only vaccinoprophylaxis makes it possible to completely liquidate an infectious disease as a nosologic unit. Unfortunately, this only relates to the so-called controllable infections, against which effective vaccines have already been developed. Vaccines have not been developed at all against many widespread infectious diseases, whose prevention can't be made by epidemiological measures. Therefore, in the next few years immunology should, on the basis of fundamental research into the mechanisms of anti-infectious immunity, find new principles of creating and using immunogenic vaccines (and these principles have already been mapped out and were mentioned above), solve the problem of reducing and liquidating in the first place emerging infectious diseases and those among them which bring uncountable harm and suffering to mankind, cause economical losses, and have an effect on the genetic structure of the human population as a whole.

Related Concept Videos

Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...