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Enzymatic synthesis of chiral intermediates for pharmaceuticals
Ramesh Patel1, Ronald Hanson, Animesh Goswami
1Process Research and Development, Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, New Jersey, 08903, USA. Patelr@bms.com
Journal of Industrial Microbiology & Biotechnology
|April 11, 2003
Abstract:
There has been an increasing awareness of the enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enatioselective manner. Chiral intermediates are in high demand by pharmaceutical industries for the preparation bulk drug substances. In this review article, microbial/enzymatic processes for the synthesis of chiral intermediates for antihypertensive drugs, melatonin receptor agonists, and beta3-receptor receptor agonists are described.