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Related Experiment Videos

Long-term experience with a preshaped left ventricular pacing lead.

Jacky Ollitrault1, Philippe Ritter, Philippe Mabo

  • 1Hôpital Européen Georges Pompidou 20, rue Leblanc, 75908 Paris, France. j.ollitrault@free.fr

Pacing and Clinical Electrophysiology : PACE
|April 12, 2003
PubMed
Summary

This study shows a new left ventricular (LV) pacing lead is successfully implanted in most patients with advanced heart failure. The lead demonstrates stable electrical properties, suggesting long-term pacemaker performance and durability.

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Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Medical Devices

Background:

  • Advanced dilated cardiomyopathy often requires cardiac resynchronization therapy (CRT).
  • Effective CRT depends on reliable left ventricular (LV) lead performance.
  • Long-term data on new LV pacing lead designs are crucial for clinical adoption.

Purpose of the Study:

  • To evaluate the long-term performance and safety of a novel LV pacing lead.
  • To assess the electrical characteristics of the lead throughout the follow-up period.
  • To determine the feasibility of implantation in patients with advanced heart failure.

Main Methods:

  • A prospective study involving 62 patients with NYHA Class III/IV heart failure and prolonged QRS duration.
  • Implantation of a new LV pacing lead with either a triple or dual chamber pacemaker.

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  • Clinical evaluations and pacemaker interrogations at multiple time points up to 7 months, with 2-year follow-up for some patients.
  • Measurement of R wave amplitude, pacing threshold, and pacing impedance.

    • Main Results:

    • Successful implantation of the LV lead in 86% of patients.
    • Mean R wave amplitude at implant was 15 ± 7 mV.
    • Pacing threshold increased from 0.73 ± 0.54 V at implant to 1.57 ± 0.60 V at 7 months (P < 0.001).
    • Mean pacing impedance remained high at 1054 ± 254 Ω, indicating low current drain.

    Conclusions:

    • The novel LV pacing lead is successfully implanted in a high percentage of patients.
    • Stable and favorable electrical parameters, including high impedance, suggest good lead longevity.
    • The lead's performance supports its use in cardiac resynchronization therapy for heart failure patients.