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Related Experiment Videos

[Obesity and reproductive disorders].

K Krizanovská1, Z Ulcová-Gallová, V Bouse

  • 1Gynekologicko-porodnická klinika, Fakultní nemocnice v Plzni, Capkovo nám 1, 307 08 Plzen, Czech Republic. krizanovska@fnplzen.cz

Sbornik Lekarsky
|April 12, 2003
PubMed
Summary

Obesity and overweight negatively impact in vitro fertilization (IVF) success rates. Obese women experience lower oocyte fertilization and clinical pregnancy rates, highlighting the need for weight management in infertility treatment.

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Area of Science:

  • Reproductive Endocrinology
  • Infertility Research
  • Assisted Reproductive Technologies

Context:

  • Obesity and overweight are linked to endocrine disorders in women, affecting ovulation and pregnancy outcomes.
  • Nutritional status, evaluated by body mass index (BMI), influences reproductive health.
  • Menstrual disturbances, including anovulation, are associated with starvation.

Purpose:

  • To investigate the impact of body mass index (BMI) on in vitro fertilization (IVF) treatment parameters and outcomes.
  • To compare IVF cycle metrics between women of varying nutritional statuses.

Summary:

  • A study of 309 IVF cycles analyzed parameters such as oocyte retrieval, fertilization, cleavage, and pregnancy rates across different BMI groups.
  • Obese and overweight women showed statistically significant reductions in fertilized oocytes and lower oocyte recovery rates.

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  • Despite high oocyte recovery and embryo cleavage rates in obese women, clinical pregnancy and take-home baby rates were lower, with increased miscarriage rates.

    • Impact:

    • Overweight and obesity significantly impair IVF treatment effectiveness, particularly oocyte fertilization and implantation potential.
    • Reduced oocyte quality and potential endometrial factors contribute to poorer IVF outcomes in obese individuals.
    • Weight reduction is a crucial component of infertility management for overweight and obese women undergoing assisted reproductive treatments.