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Solid-phase synthesis of naltrindole derivatives using Fischer indole synthesis based on one-pot release and
Hiroshi Tanaka1, Hiroshi Ohno, Kuniaki Kawamura
1Department of Applied Chemistry, Tokyo Institute of Technology, Meguro, Tokyo 152-8552, Japan.
Organic Letters
|April 12, 2003
Abstract:
[reaction: see text] We describe a new approach for the solid-phase synthesis of indoles 1 that involves a one-pot release and cyclization reaction of a solid-supported hydrazone through a Wang-type linker. Using this solid-phase methodology, we accomplished the synthesis of 40 naltrindole derivatives.