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Fluorous solvent as a new phase-screen medium between reagents and reactants in the bromination and chlorination of
Hiroyuki Nakamura1, Taikou Usui, Hirokazu Kuroda
1Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Tokyo 171-8588, Japan. hiroyuki.nakamura@gakushuin.ac.jp
Organic Letters
|April 12, 2003
Abstract:
[reaction: see text] A perfluorohexane layer regulates the rate of reagent transport in the bromination and chlorination of alcohols. A fluorous triphasic U-tube method is effective for lighter reagents; the thionyl chloride layer (yellow) vanishes, and the chlorides are obtained from the right top organic layer in the chlorination of alcohols.