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Efficient entry into medium-ring keto-lactones. The ruthenium tetraoxide-promoted oxidative cleavage of
Helena M C Ferraz1, Luiz S Longo
1Instituto de Química, Universidade de São Paulo, CEP 05508-900, São Paulo SP, Brazil. hmferraz@iq.usp.br
Organic Letters
|April 12, 2003
Abstract:
[reaction: see text] A new use of ruthenium tetraoxide is reported. The catalytic oxidative cleavage of hexahydro-benzofuran-3a-ols led to nine-membered ring keto-lactones in moderate to good yields and high purity. The reaction is clean and easily performed using catalytic amounts of ruthenium trichloride and an excess of sodium periodate as a cooxidant.