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Percolation, morphogenesis, and burgers dynamics in blood vessels formation
A Gamba1, D Ambrosi, A Coniglio
1Dipartimento di Matematica, Politecnico di Torino, 10129 Torino, Italia.
Physical Review Letters
|April 12, 2003
Abstract:
Experiments of in vitro formation of blood vessels show that cells randomly spread on a gel matrix autonomously organize to form a connected vascular network. We propose a simple model which reproduces many features of the biological system. We show that both the model and the real system exhibit a fractal behavior at small scales, due to the process of migration and dynamical aggregation, followed at large scale by a random percolation behavior due to the coalescence of aggregates. The results are in good agreement with the analysis performed on the experimental data.