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From knowing to controlling: a path from genomics to drugs using small molecule probes
Robert L Strausberg1, Stuart L Schreiber
1Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Bethesda, MD 20892, USA. RLS@nih.gov
Science (New York, N.Y.)
|April 12, 2003
Summary
The National Cancer Institute
Area of Science:
- Chemical genetics
- Molecular biology
- Bioinformatics
Background:
- The National Cancer Institute (NCI) supports chemical genetics research.
- Small molecular probes are essential tools in chemical genetics.
- Understanding gene product function is crucial in normal and disease states.
Purpose of the Study:
- To promote the development and utilization of chemical genetics.
- To create resources for discerning gene product functions.
- To bridge the gap between genomic discovery and drug development.
Main Methods:
- Development of small molecular probes for protein modulation.
- Establishment of ChemBank, a suite of informatics tools and databases.
- Facilitating global scientific access to chemical genetics resources.
Main Results:
- Creation of resources to aid in understanding gene product roles.
- Establishment of ChemBank to support chemical genetics research.
- Providing a pathway from genomic data to potential therapeutic targets.
Conclusions:
- The NCI's initiative fosters chemical genetics research.
- ChemBank serves as a vital resource for the scientific community.
- This initiative is instrumental in advancing drug discovery pipelines.
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