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Elastin polymorphism haplotype and intracranial aneurysms are not associated in Central Europe
Anne Hofer1, Marcella Hermans, Nina Kubassek
1Department of Neurology, Johann Wolfgang Goethe-University Frankfurt am Main, Germany.
Background And Purpose:
The occurrence of intracranial aneurysms and of aneurysmal subarachnoid hemorrhage are influenced by genetic factors. Recent genomic studies in Japan have defined 3 chromosomal loci and 1 haplotype of elastin polymorphisms as important risk factors, both for affected sib pairs and sporadic patients.
Methods:
We have genotyped 2 single nucleotide polymorphisms in the elastin gene and evaluated their allelic association with intracranial aneurysm in a Central European sample of 30 familial and 175 sporadic patients and 235 population controls.
Results:
We found no allelic association between this elastin polymorphism haplotype and intracranial aneurysm.
Conclusions:
Our data probably reflect increased genetic heterogeneity of intracranial aneurysm in Europe compared with Japan.