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[Oxidative stress profile: OSP]
1Japan Institute for the Control of Aging, Fukuroi 437-0122.
Rinsho Byori. the Japanese Journal of Clinical Pathology
|April 15, 2003
Summary
Oxidative stress, linked to aging and disease, can now be evaluated using the new Oxidative Stress Profile (OSP) system. This diagnostic tool assesses biomarkers and reveals that lifestyle changes can significantly reduce oxidative stress levels.
Area of Science:
- Biochemistry
- Medical Diagnostics
- Preventive Medicine
Background:
- Oxidative stress is implicated in aging and various diseases, including inflammation, carcinogenesis, arteriosclerosis, and ischemia-reperfusion injury.
- In vivo evaluation and control of oxidative stress are crucial for disease prevention and aging management.
Purpose of the Study:
- To introduce the novel Oxidative Stress Profile (OSP) system, a comprehensive diagnostic tool for assessing human oxidative stress.
- To evaluate the effectiveness of the OSP system in identifying elevated oxidative stress in specific populations and its response to lifestyle modifications.
Main Methods:
- Developed the Oxidative Stress Profile (OSP) system, integrating biomarkers for oxidative damage, prooxidant factors, antioxidants, and lifestyle factors.
- Measured a panel of biomarkers including oxidative damage markers and serum antioxidants.
- Analyzed oxidative stress levels and presented results in a two-dimensional plot format.
Main Results:
- The OSP system indicated elevated oxidative stress in diabetic patients compared to healthy controls.
- Smokers exhibited higher levels of oxidative stress than non-smokers.
- Significant reduction in oxidative stress was observed following lifestyle improvements, such as dietary changes.
Conclusions:
- The Oxidative Stress Profile (OSP) system offers a powerful method for in vivo oxidative stress evaluation.
- The OSP system shows potential utility in disease prevention, "mi-byo" (pre-disease) diagnosis, and aging control.