Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene polymorphisms, inflammatory diseases and cancer.

W Martin Howell1, Philip C Calder, Robert F Grimble

  • 1Histocompatibilizy & Immunogenetics Laboratory/Human Genetics Division, Southampton University Hospitals, Southampton SO16 6YD, UK. wmh1@soton.ac.uk

The Proceedings of the Nutrition Society
|April 15, 2003
PubMed
Summary

Genetic variations in human leucocyte antigen (HLA) and cytokine genes significantly impact immune responses and disease susceptibility. Specific HLA and cytokine gene polymorphisms are linked to autoimmune diseases, cancers, and dietary intolerances, influencing disease risk and outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased Plasma L-Arginine Levels and L-Arginine/ADMA Ratios after Twelve Weeks of Omega-3 Fatty Acid Supplementation in Amateur Male Endurance Runners.

Nutrients·2022
Same author

Models predict change in plasma triglyceride concentrations and long-chain n-3 polyunsaturated fatty acid proportions in healthy participants after fish oil intervention.

Frontiers in nutrition·2022
Same author

Urinary Leukotriene E4 as a Biomarker in NSAID-Exacerbated Respiratory Disease (N-ERD): a Systematic Review and Meta-analysis.

Current allergy and asthma reports·2022
Same author

Improved Oxygen Uptake Efficiency Parameters Are Not Correlated with VO<sub>2peak</sub> or Running Economy and Are Not Affected by Omega-3 Fatty Acid Supplementation in Endurance Runners.

International journal of environmental research and public health·2022
Same author

Incubator type affects human blastocyst formation and embryo metabolism: a randomized controlled trial.

Human reproduction (Oxford, England)·2022
Same author

The Plasma Oxylipin Signature Provides a Deep Phenotyping of Metabolic Syndrome Complementary to the Clinical Criteria.

International journal of molecular sciences·2022

Area of Science:

  • Immunogenetics
  • Molecular immunology
  • Disease genetics

Background:

  • Human leucocyte antigen (HLA) and cytokine genes are crucial for immune response regulation.
  • HLA genes exhibit high polymorphism, affecting peptide antigen presentation to T-cells.
  • Cytokine gene polymorphisms, often in promoter regions, influence inflammatory gene product expression.

Purpose of the Study:

  • To explore the association between HLA and cytokine gene polymorphisms and various diseases.
  • To investigate the role of these genetic variations in immune-mediated conditions, cancers, and dietary interactions.
  • To examine the potential for genotype-dependent dietary modulation of cytokine expression.

Main Methods:

  • Analysis of genetic polymorphisms in HLA and cytokine genes.

Related Experiment Videos

  • Association studies linking specific genotypes to disease susceptibility and prognosis.
  • Investigation of in vitro gene expression and potential dietary influences.

    • Main Results:

    • Specific HLA genotypes (e.g., HLA-DQA1*0501, DQB1*0201) confer a significantly increased risk for coeliac disease.
    • HLA polymorphisms are associated with rheumatoid arthritis and may influence lymphoma risk in coeliac patients.
    • Cytokine gene polymorphisms are implicated in susceptibility and prognosis of cancers (melanoma, prostate) and gut diseases, with potential genotype-dependent dietary modulation.

    Conclusions:

    • HLA and cytokine gene polymorphisms are key genetic determinants of immune-mediated diseases and cancer risk.
    • Understanding these genetic factors can improve disease risk assessment and prognosis.
    • Dietary interventions may need to consider individual genetic profiles for optimal immune modulation.