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Scanning electron microscopy of surface irregularities and thrombogenesis of polyurethane and polyethylene coronary

M G Bourassa, M Cantin, E B Sandborn

    Circulation
    |June 1, 1976
    PubMed

    Insights

    Catheter surface irregularities significantly increase thrombosis risk during coronary arteriography. Smooth, high-quality catheter materials are crucial for preventing blood clots and thromboembolic complications.

    Area of Science:

    • Cardiovascular Medicine
    • Biomaterials Science
    • Medical Device Engineering

    Background:

    • Coronary arteriography involves inserting catheters into coronary arteries.
    • Catheter surface properties can influence thrombogenesis (blood clot formation).
    • Previous studies suggest a link between catheter surface irregularities and thrombosis.

    Purpose of the Study:

    • To compare the surface characteristics and thrombogenic potential of polyurethane and polyethylene coronary catheters.
    • To investigate the role of surface irregularities in catheter-associated thrombosis.

    Main Methods:

    • Scanning electron microscopy (SEM) was used to examine the inner and outer surfaces of polyurethane and polyethylene coronary catheters.
    • The presence and location of thrombi (blood clots) on catheter surfaces were analyzed.

    Main Results:

    • Polyurethane catheters exhibited rough internal and external surfaces, with thrombi found on both.
    • Polyethylene catheters had a smoother internal surface but irregular external surfaces, with thrombi primarily on the exterior.
    • Thrombosis was observed on the internal surfaces of some polyurethane catheters and, to a lesser extent, on polyethylene catheters.

    Conclusions:

    • Internal and external surface irregularities of intravascular catheters are major contributors to thrombosis.
    • High-quality catheter materials with smooth surfaces are essential for preventing thromboembolic complications during procedures like coronary arteriography.

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