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Related Experiment Videos

Joule heating during solid tissue electroporation.

U Pliquett1

  • 1University of Bielefeld, Bielefeld, Germany. uwe.pliquett@uni-bielefeld.de

Medical & Biological Engineering & Computing
|April 15, 2003
PubMed
Summary
This summary is machine-generated.

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High-voltage pulses cause electroporation and heating in biological tissues. Temperature increases, especially near electrodes, can influence electroporation, aiding electrode optimization for medical applications.

Area of Science:

  • Biophysics
  • Biomedical Engineering

Background:

  • High-voltage pulses induce electroporation (pore creation) and significant Joule heating in biological tissues.
  • Understanding the interplay between electrical fields, tissue properties, and thermal effects is crucial for electroporation applications.

Purpose of the Study:

  • To investigate the combined effects of electroporation and Joule heating in biological tissues under high-voltage pulse application.
  • To theoretically model and experimentally validate temperature changes during electroporation.
  • To explore the influence of electrode configuration on temperature distribution and its impact on electroporation.

Main Methods:

  • Combined experimental and theoretical approach.
  • Application of high-voltage pulses (1.25 kV cm(-1), 6 ms) to biological tissue.

Related Experiment Videos

  • Theoretical modeling of temperature rise and distribution, considering electric field strength and heat transfer.
  • Experimental validation using myocardial tissue (conductivity 0.5 S m(-1)).

    • Main Results:

    • Theoretical temperature rise of approximately 11.2 K for a 1.25 kV cm(-1), 6 ms pulse in myocardial tissue.
    • Temperature increases primarily at needle electrode sites due to inhomogeneous electric fields.
    • In highly conductive tissues like muscle, bulk temperature effects were observed.
    • Observed temperature changes can influence the stability of electroporation-induced aqueous pathways.

    Conclusions:

    • Joule heating is a significant secondary effect of high-voltage pulse application in biological tissues.
    • Electrode design and placement critically influence local temperature rise, impacting electroporation efficacy.
    • Modeling temperature distribution is valuable for optimizing electrode configurations in electroporation therapies.