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Campylobacter jejuni O:19 serotype-associated Guillain-Barré syndrome in a child: the first case reported from Greece

S Chatzipanagiotou1, K Kilidireas, G Trimis

  • 1Department of Clinical Microbiology, Aeginition Hospital, Medical School of Athens, Vass. Sophias av. 72-4, 115 28 Athens, Greece. chatlouk@hotmail.com

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|April 15, 2003
PubMed

Insights

This study reports a child with Guillain-Barré syndrome (GBS) after Campylobacter jejuni infection. The findings link C. jejuni to GBS through specific antibodies and genetic markers.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Immunology

Background:

  • Guillain-Barré syndrome (GBS) is an autoimmune disorder affecting the peripheral nervous system.
  • Campylobacter jejuni infections are a known trigger for GBS, particularly in certain populations.
  • Understanding the specific serotypes and genetic predispositions is crucial for GBS research.

Observation:

  • A pediatric case of GBS following infection with Campylobacter jejuni HS serotype O:19 is presented.
  • The patient exhibited positive antibodies against C. jejuni and autoantibodies targeting peripheral nerve ganglioside GM1.
  • The patient was positive for HLA-B35 and HLA-DR8 antigens, genetic markers associated with C. jejuni-triggered GBS.

Findings:

  • The presence of anti-C. jejuni and anti-GM1 antibodies strongly correlates with the diagnosis of GBS.
  • The identified HLA antigens (HLA-B35, HLA-DR8) in the patient align with previously observed genetic associations in C. jejuni-related GBS.
  • This case represents the first documented instance of C. jejuni-associated GBS in Greece.

Implications:

  • This case highlights the importance of recognizing C. jejuni as a potential cause of GBS in pediatric patients.
  • Further epidemiological and clinical studies are needed to confirm the association and prevalence of C. jejuni-associated GBS in Greece.
  • Identifying specific triggers and host factors can improve GBS diagnosis and potentially inform future treatment strategies.

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