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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Serum sialic acid, a reputed cardiovascular risk factor, is related to serum leptin concentrations in Fijians
M A Crook1, J Miell, P Ameerally
1Department of Chemical Pathology, Guy's, St. Thomas' and University Hospital, 5th Floor Tower, Lewisham, London, SE1 9RT, UK. martin.crook@gstt.sthames.nhs.uk
Background:
Serum sialic acid (TSA) has been shown to be a cardiovascular risk factor and an acute phase reactant, with elevated concentrations associated with increased cardiovascular mortality and to precede the onset of type 2 diabetes.
Aim:
The purpose of this present study was to test the hypothesis that serum TSA may be related to serum leptin concentrations in healthy individuals.
Methods:
Thirty Fijian individuals were studied (8 males and 22 females). They were urban Melanesians living in Raiwaga, a suburb of Suva in Fiji.
Results:
Serum TSA significantly correlated with subject body mass index (BMI, rho 0.39, P<0.05) and serum leptin concentration (rho 0.44, P<0.05). In stepwise multiple regression analysis serum TSA independently correlated with subject waist/hip ratio (r(2)=0.167, P<0.02) and diastolic blood pressure (r(2)=0.300, P<0.01) but not with age, BMI, serum insulin-like growth factor binding protein (IGFBP-1), fasting plasma glucose or systolic or diastolic blood pressure.
Conclusions:
Serum TSA is related to markers of obesity and adipose tissue metabolism which may help to explain why it is a reputed cardiovascular risk factor and why elevated serum TSA concentrations precede the development of type 2 diabetes mellitus.
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