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[Regional isolated perfusion: also applicable in elderly patients].

E M Noorda1, B C Vrouenraets, O E Nieweg

  • 1Nederlands Kanker Instituut/Antoni van Leeuwenhoek Ziekenhuis, afd. Chirurgische Oncologie, Plesmanlaan 121, 1066 CX Amsterdam. e.noorda@nki.nl

Nederlands Tijdschrift Voor Geneeskunde
|April 16, 2003
PubMed
Summary

Isolated limb perfusion effectively saved limbs in 3 elderly patients with advanced cancers. This treatment offers a safe and viable option for older individuals facing unresectable extremity tumors.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Geriatric Medicine

Background:

  • Elderly patients (>75 years) with advanced extremity malignancies often have limited treatment options.
  • Unresectable tumors pose significant challenges for limb salvage and quality of life.

Observation:

  • Three elderly female patients (82, 78, and 83 years) with advanced lower leg melanoma and lower arm sarcoma were treated.
  • The patients had extensive, locoregional, or recurrent malignancies.
  • Treatment involved isolated limb perfusion with melphalan, with or without tumor necrosis factor alpha.

Findings:

  • Limb salvage was successfully achieved in all three patients.
  • The procedure was well-tolerated with no reported complications.
  • All patients experienced good recovery and maintained their limbs.

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Implications:

  • Isolated limb perfusion is a safe and effective treatment for unresectable extremity tumors in elderly patients.
  • This technique offers a valuable option for limb salvage, improving long-term outcomes and quality of life in geriatric oncology.
  • Further research may explore expanding the application of isolated limb perfusion in older populations.