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Updated: Sep 26, 2026

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
Published on: September 19, 2016
[Lymphadenitis as a complication following vaccination with Bacillus Calmette-Guérin (BCG)]
E Cerdá de Palou1, H P R M de Santy
1GGD Oostelijk Zuid-Limburg, Postbus 155, 6400 AD Heerlen. cerdab@ggdozl.nl
Abstract:
A healthy 14-months-old boy developed suppurative adenitis some weeks after Bacillus Calmette Guérin (BCG) vaccination. The tumour grew rapidly, showed fluctuation and eventually incision was needed. Culture of the abscess was negative. The diagnosis was: regional lymphadenitis after BCG vaccination. This suppurative lymphadenitis is a non-serious complication of BCG vaccination and has been reported in 0.1 to 4% of those vaccinated. As the BCG vaccination is given only to the at-risk population in the Netherlands, BCG complications are rare. Non-suppurative nodal swellings are considered a normal post-vaccination reaction and do not require treatment.
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