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Colorectal cancer in younger patients
L J Singh1, G S Moirangthem, K Debnath
1Department of Radiotherapy, Regional Institute of Medical Sciences, Imphal, India.
Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation
|April 16, 2003
Summary
Colorectal cancer in young adults (21-30 years) is presenting at advanced stages in India, with rectal bleeding as a common symptom. Outcomes are poor, even with treatment, highlighting a need for earlier detection strategies.
Area of Science:
- Oncology
- Gastroenterology
- Public Health
Background:
- Colorectal cancer (CRC) is rare in India, especially in individuals under 40.
- Early-onset CRC presents unique challenges in diagnosis and management.
Purpose of the Study:
- To analyze the clinical characteristics, treatment, and outcomes of colorectal cancer in young adults (21-30 years) in India.
- To understand the incidence and presentation of early-onset CRC in this demographic.
Main Methods:
- Retrospective analysis of 18 patients aged 21-30 years diagnosed with colorectal cancer.
- Evaluation of tumor site, presenting symptoms, histopathology, TNM staging, treatment received, and survival data.
Main Results:
- Rectal adenocarcinoma was most common (83%), with rectal bleeding as the primary symptom (89%).
- 50% had poorly differentiated adenocarcinoma; 28% had unresectable tumors.
- 78% presented with advanced stage (TNM III/IV).
- Only 3 of 13 surgically treated patients achieved >2 years disease-free survival.
Conclusions:
- Colorectal cancer in young adults is not as infrequent as previously thought and often presents at an advanced stage.
- Poor outcomes are observed, emphasizing the need for increased awareness and improved diagnostic approaches for early-onset CRC.