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Flutamide-induced hepatotoxicity with possible potentiation by simvastatin
Unnati Ashar1, D Desai, Anita Bhaduri
1Department of Medicine, PD Hinduja Hospital and Medical Research Centre, Veer Savarkar Road, Mahim, Mumbai 400 016.
The Journal of the Association of Physicians of India
|April 16, 2003
Abstract:
We report a 65 years old male who presented with jaundice in February 2000. He was operated for prostate carcinoma and started on flutamide in May 1999. He developed anorexia in mid January and frank jaundice by end February. LFT showed cholestatic picture. Liver biopsy showed cholestasis. Flutamide was stopped and patient made slow recovery. Possible additional hepatotoxicity of simvastatin is discussed.