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Updated: Jul 22, 2026

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
Published on: September 11, 2018
The anaesthetic management of a patient with a reninoma
J P Nicholson1, G Rayman, P Donaldson
1Specialist Registrar in Anaesthesia, Consultant Endocrinologist, Consultant Urologist and Consultant Anaesthetist, The Ipswich Hospital, Heath Road, Ipswich IP4 5 PD, UK.
Abstract:
We report on the anaesthetic management of a 28-year-old woman presenting for excision of a reninoma. This is a very rare tumour of the juxtaglomerular cells of the kidney, which can be cured immediately by surgery. Previous reports have failed to record the presence or absence of peri-operative cardiovascular lability. We have shown that blood pressure, cardiac index (CI) and systemic vascular resistance (SVRI) were remarkably stable in our patient throughout surgery, even during manipulation of the tumour. Isolation of the tumour was associated with a 23% reduction in SVRI, and a similar decrease in blood pressure. The cardiovascular lability associated with the removal of catecholamine-secreting tumours was not seen in this case.
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