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Relationship between advanced glycoxidation end products, inflammatory markers/acute-phase reactants, and some
Marta Kalousová1, Tomás Zima, Vladimír Tesar
1Institute of Medical Biochemistry, 1st Department of Medicine, Division of Nephrology, and 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. mkalousova@hotmail.com
Abstract:
Uremia and dialysis treatment are associated with uncorrected oxidative and carbonyl stress and microinflammation. Elevation of both oxidative/carbonyl stress end products (advanced oxidation protein products (AOPP), advanced glycation end products (AGEs), and advanced lipoperoxidation end products (ALEs), autoantibodies against modified biological structures, and acute-phase reactants (e.g., C-reactive protein [CRP], fibrinogen) seems to take part in the development of various complications, among them accelerated atherosclerosis. These pathogenic mechanisms are supposed to act synergically; nevertheless, oxidative stress shows a closer relationship to inflammation and acute-phase reaction than advanced glycation. Its end product, AOPP, could, thus, represent a biochemical marker of specific importance.
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