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Related Experiment Videos

Pressure wave reflection assessed from the peripheral pulse: is a transfer function necessary?

Sandrine C Millasseau1, Sundip J Patel, Simon R Redwood

  • 1Department of Clinical Pharmacology, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK.

Hypertension (Dallas, Tex. : 1979)
|April 16, 2003
PubMed
Summary
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Estimating central pressure wave reflection using a transfer function to the radial pulse is questionable. A direct radial augmentation index closely correlates with the aortic augmentation index, suggesting a simpler method.

Area of Science:

  • Cardiovascular Physiology
  • Biomedical Engineering
  • Hypertension Research

Background:

  • Aortic pressure waveform synthesis using transfer functions estimates central blood pressure and augmentation index.
  • The accuracy of transfer functions for deriving the aortic augmentation index (AI) is debated.
  • Alternative methods may provide similar insights into central pressure wave reflection.

Purpose of the Study:

  • To compare aortic systolic blood pressure and AI derived from carotid and radial arteries using transfer functions.
  • To evaluate the correlation between AI and a radial augmentation index (RAI) calculated without a transfer function.
  • To assess the impact of vasoactive drugs on AI and RAI.

Main Methods:

  • Arterial tonometry (Sphygmocor) was applied to 84 subjects (healthy, hypertension, coronary artery disease).

Related Experiment Videos

  • Aortic and radial augmentation indices were calculated with and without transfer functions.
  • Pharmacological studies involved nitroglycerine and norepinephrine administration in 12 healthy volunteers.

    • Main Results:

    • Aortic systolic pressure estimation showed acceptable agreement between radial and carotid arteries (R=0.98).
    • Aortic augmentation index derived via transfer function showed poor agreement (R=0.47), especially in controls.
    • Aortic augmentation index strongly correlated with the radial augmentation index (R=0.96), with parallel drug responses.

    Conclusions:

    • The use of transfer functions to derive the aortic augmentation index is questionable.
    • A direct radial augmentation index provides reliable information on central pressure wave reflection.
    • This suggests a simpler, non-transfer function-based approach for assessing central hemodynamics.