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Updated: Sep 26, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
Yeast POL5 is an evolutionarily conserved regulator of rDNA transcription unrelated to any known DNA polymerases
Wei Yang1, Igor B Rogozin, Eugene V Koonin
1National Center for Biotechnology Inforamtion, National Library of Medicine, National Institutes of Health; Bethesda, Maryland 20894, USA.
Abstract:
We show that yeast protein Yel055cp, which has been identified as the fifth essential DNA polymerase in Saccharomyces cerevisiae (POL5), is a member of a family of predicted rDNA transcription regulators (typified by human MYB-binding protein MYBBP1 A), which are represented by a single ortholog in all animals, fungi and plants with sequenced genomes. These proteins are confidently predicted to have an entirely a-helical structure and are unrelated to the B class DNA polymerases, as claimed for yeast POL5, or any other known polymerases.
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