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Updated: Aug 19, 2026

A Strategy for Sensitive, Large Scale Quantitative Metabolomics
Published on: May 27, 2014
[Reference values of solvents and metabolites in biological samples]
G B Bartolucci1, P Bavazzano, A Perico
1Dipartimento di Medicina Ambientale e Sanità Pubblica, Università degli Studi di Padova.
Abstract:
This article presents a review of reference values for organic solvent biomarkers. Some of these results were obtained in the research activities of the Italian Society Reference Values (SIVR). Most experiences show data obtained from control groups during occupational exposures assessment investigations. We considered only data related to the following biomarkers: immodified solvents in blood and urine, their main urinary metabolites. The reference values of the following solvents are reported: benzene, toluene, xylene, nhexane, cyclohexane, trichloroethylene, perchloroethylene, methanol, acetone, N,N-dimethylformamide, carbon disulphide. In the text also the influence of some confounding factors is discussed.
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