Related Experiment Video
Updated: Jul 18, 2026

DiOLISTIC Labeling of Neurons from Rodent and Non-human Primate Brain Slices
Published on: July 6, 2010
Ruthenium-mediated regio- and stereoselective alkenylation of pyridine
Masahiro Murakami1, Seiji Hori
1Department of Synthetic Chemistry, Kyoto University, Yoshida, Kyoto 606-8501, Japan.
Abstract:
A novel alkenylation reaction of pyridine is developed. Heating a cationic ruthenium vinylidene complex [CpRu(=C=CHR)(PPh(3))(2)]PF(6) in pyridine at 100-125 degrees C for 24 h affords (E)-2-alkenylpyridine. Initially, pyridine coordinates to ruthenium by displacement of one of the phosphine ligands. Then, [2 + 2] heterocycloaddition occurs to form a four-membered ruthenacyclic complex. Deprotonation of the beta-hydrogen affords a neutral pi-azaallyl complex. Protonolysis furnishes the product. As a result, a vinylidene group is inserted into the alpha C-H bond of pyridine. The alkenylation reaction is made catalytic in ruthenium by the use of (alkyn-1-yl)silane as the vinylidene source. Treatment of (alkyn-1-yl)trimethylsilane with pyridine in the presence of a cationic ruthenium complex [CpRu(PPh(3))(2)]PF(6) affords the corresponding (E)-2-alkenylpyridine in good yield in a regio- and stereoselective manner.
Related Concept Videos
Basal Lamina are the Specialized Form of ECM
Proteins...
Phase Contrast and Differential Interference Contrast Microscopy
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
Gestalt Principles of Perception
Second Derivatives of Implicit Functions
Area Between Curves: Integrating With Respect to y
Area Between Curves: Problem Solving

