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Adaptive immune response of Vgamma2Vdelta2 T cells: a new paradigm
Zheng W Chen1, Norman L Letvin
1Tuberculosis Research Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, RE113/RE216, Boston, MA 02115, USA. zchen@caregroup.harvard.edu
Trends in Immunology
|April 17, 2003
Abstract:
The role of gammadelta T cells in adaptive immunity remains uncertain. Recent studies have demonstrated that a unique subset of gammadelta T cells in primates can mount adaptive immune responses during mycobacterial infections. This Review discusses notable similarities and differences in adaptive immune responses between non-peptide-specific gammadelta T cells and peptide-specific alphabeta T cells, and discusses both the molecular basis for gammadelta T-cell responses and potential functions of these enigmatic cells.