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Three-dimensional porous poly-DL-lactide/basic fibroblast growth factor composites for bone defect repair: an
Shao-xiong Min1, An-min Jin, Bin-hui Tong
1Department of Orthopedics and Spine, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. msxbear24@yahoo.com.cn
Di 1 Jun Yi Da Xue Xue Bao = Academic Journal of the First Medical College of PLA
|April 17, 2003
Summary
Basic fibroblast growth factor (bFGF) combined with porous poly-DL-lactide (PDLLA) significantly enhanced bone formation and strength in rabbit radial defects. This composite shows promise as a new absorbable osteosynthesis material.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Orthopedic Surgery
Background:
- Poly-DL-lactide (PDLLA) is a biocompatible and absorbable polymer.
- Porous PDLLA scaffolds can support bone regeneration.
- Basic fibroblast growth factor (bFGF) is a potent osteoinductive agent.
Purpose of the Study:
- To evaluate the osteoinductive potential of PDLLA/bFGF composites.
- To develop a novel absorbable material for osteosynthesis.
Main Methods:
- Porous PDLLA foams (150-300 µm pores) were fabricated using solvent-casting and particulate-leaching.
- Rabbit radial defects were treated with PDLLA, PDLLA/bFGF, or left untreated (control).
- Assessments included X-ray, histology, SEM, and biomechanical testing at 2, 4, 8, and 12 weeks.
Main Results:
- PDLLA/bFGF composites demonstrated significantly greater bone formation and bending strength compared to PDLLA alone (P<0.05).
- Both PDLLA and PDLLA/bFGF groups showed significantly more bone formation than the control group at all time points (P<0.05).
Conclusions:
- Porous PDLLA exhibits good biocompatibility, absorbability, and osteoconductivity.
- PDLLA/bFGF foam acts as an effective carrier for bFGF, promoting rapid, abundant, and high-quality bone formation.
- This composite material shows significant osteoinductive ability for bone defect repair.