Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Long-term outcome after ischaemic stroke/transient ischaemic attack.

Graeme J Hankey1

  • 1Stroke Unit, Royal Perth Hospital and Department of Medicine, University of Western Australia, Perth, WA, Australia. gjhankey@cyllene.uwa.edu.au

Cerebrovascular Diseases (Basel, Switzerland)
|April 17, 2003
PubMed
Summary

Stroke outcomes depend on severity, age, and prior health. Early mortality is linked to stroke severity, while long-term survival hinges on managing cardiovascular disease and preventing recurrent strokes through risk factor control and antiplatelet therapy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protocol of a randomized controlled trial investigating the effectiveness of Recovery-focused Community support to Avoid readmissions and improve Participation after Stroke (ReCAPS).

International journal of stroke : official journal of the International Stroke Society·2021
Same author

Twelve-Month Outcomes of the AFFINITY Trial of Fluoxetine for Functional Recovery After Acute Stroke: AFFINITY Trial Steering Committee on Behalf of the AFFINITY Trial Collaboration.

Stroke·2021
Same author

Renal Impairment and Risk of Acute Stroke: The INTERSTROKE Study.

Neuroepidemiology·2021
Same author

Ischemic Events After Intracerebral Hemorrhage: A New Target for Secondary Prevention.

JAMA neurology·2021
Same author

Secondary Prevention of Stroke: Study Protocol for a Telehealth-Delivered Physical Activity and Diet Pilot Randomized Trial (ENAbLE-Pilot).

Cerebrovascular diseases (Basel, Switzerland)·2021
Same author

Plasma Amyloid-Beta Levels in a Pre-Symptomatic Dutch-Type Hereditary Cerebral Amyloid Angiopathy Pedigree: A Cross-Sectional and Longitudinal Investigation.

International journal of molecular sciences·2021

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Public Health

Background:

  • Stroke presents a significant early mortality risk (25% within 30 days), primarily due to the index event and its complications.
  • Stroke severity, advanced age, prior stroke history, cardiac failure, hyperglycemia, and elevated white blood cell count are key predictors of short-term mortality.
  • Cardiovascular disease emerges as the leading cause of death 1-5 years post-stroke, underscoring the systemic nature of atherothrombosis.

Purpose of the Study:

  • To identify predictors of early (30-day) and long-term (1-5 year) mortality and disability after stroke.
  • To elucidate the risk factors and patterns of recurrent cerebrovascular events and cardiovascular events post-stroke.
  • To inform clinical strategies for optimizing long-term outcomes by mitigating risks of recurrence and cardiovascular events.

Related Experiment Videos

Main Methods:

  • Retrospective analysis of patient data to identify mortality and disability predictors.
  • Statistical modeling to assess the impact of various clinical factors on short-term and long-term outcomes.
  • Evaluation of the incidence and timing of recurrent cerebrovascular and coronary events.

Main Results:

  • Stroke severity is the most consistent predictor of 30-day mortality; age and cardiac failure are robust predictors of 1-5 year mortality.
  • The risk of recurrent cerebrovascular events is highest within the first month and year post-stroke, particularly for atherosclerotic strokes.
  • Diabetes is the strongest predictor of stroke recurrence over 5 years, while large-artery atherosclerosis with significant stenosis predicts early recurrence.
  • At 5 years, approximately 40% of stroke survivors have significant disability, with age, stroke severity, and recurrence being key predictors.

Conclusions:

  • Optimizing long-term outcomes requires aggressive management of vascular risk factors and prevention of recurrent strokes and coronary events.
  • Targeted interventions, including plaque stabilization, risk factor control, and long-term antiplatelet therapy, are crucial for improving patient survival and function.
  • Understanding the distinct predictors of early versus late recurrence and disability is essential for personalized stroke management strategies.