Ocular Hypertension Treatment Study (OHTS) commentary
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Updated: Jul 22, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
Published on: March 12, 2016
1Creighton University School of Medicine, Omaha, Nebraska 68178, USA.
Purpose Of Review:
To summarize the major findings of the Ocular Hypertension Treatment Study (OHTS).
Recent Findings:
Ocular hypertensive subjects who received topical glaucoma medication experienced conversion to glaucoma at less than half the rate of subjects who were monitored without treatment. Risk factors for converting to glaucoma included older age, higher intraocular pressure, larger cup-disc ratio, higher pattern SD, and thinner central corneal thickness.
Summary:
The OHTS clearly established that medically treating ocular hypertension is efficacious in delaying or preventing the onset of glaucoma. Further, the results may assist in providing useful guidelines for determining who with ocular hypertension should be offered medical treatment.
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