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Updated: Aug 19, 2026

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
Published on: October 29, 2015
[3-substituted analogs of remantadine: synthesis and antiherpetic activity in Vero cells]
I K Moiseev1, V L Andronova, V V Pozdniakov
1D. I. Ivanovsky Research Institure of Virology Russian Academy of Medical Sciences, Moscow.
Abstract:
Chemical synthesis of 3-substituted analogues of remantadine is described. Derivatives IIIb and IIIc when compared with remantadine had not only potent activity against ethalon herpes simplex type 1 virus strain but also were active against herpes virus resistant to aciclovir. Compound IIIc demonstrated virulecidal effect. Combination of IIIc + aciclovir had additive effect against ethalon herpes simplex type 1 virus strain. Investigated 3-substituted analogues demonstrated low activity in the model system of influenzae virus. No antiviral activity was demonstrated in the model system of Syndbys virus (though compounds were evaluated in subtoxic concentrations).
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