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Thrombocytosis in patients with celiac sprue
Gastroenterology
|June 1, 1976
Summary
Peripheral blood thrombocytosis, a high platelet count, was observed in 57% of celiac sprue patients. This condition resolved with treatment, indicating its role in assessing active celiac disease.
Area of Science:
- Gastroenterology
- Hematology
Background:
- Celiac sprue is a condition affecting the small intestine.
- Thrombocytosis, or elevated platelet count, can be associated with various medical conditions.
Purpose of the Study:
- To investigate the prevalence and significance of peripheral blood thrombocytosis in patients with celiac sprue.
- To determine if thrombocytosis correlates with disease activity or nutritional deficiencies in celiac sprue.
Main Methods:
- Clinical assessment and small bowel biopsy were used to diagnose celiac sprue.
- Peripheral blood platelet counts were measured in patients with active disease and during remission.
- Serum levels of iron, folate, and vitamin B12 were analyzed for correlation with thrombocytosis.
Main Results:
- Peripheral blood thrombocytosis was present in 57% of celiac sprue patients (12/25).
- Platelet counts significantly decreased after achieving clinical and histological remission.
- No correlation was found between thrombocytosis and serum iron, folate, or vitamin B12 levels.
Conclusions:
- Thrombocytosis in celiac sprue reflects active disease and is not present during remission.
- Celiac sprue should be considered in the differential diagnosis of thrombocytosis, alongside inflammatory bowel disease.
- Evaluating peripheral blood platelets may aid in assessing celiac sprue activity.
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