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Screening for renal cell carcinoma using ultrasonography: a feasibility study
D Filipas1, C Spix, D Schulz-Lampel
1Department of Urology, University of Mainz. dragana.filipas@uro.akh.magwien.gv.at
BJU International
|April 18, 2003
Summary
Systematic renal cell carcinoma (RCC) screening using ultrasonography (US) proved practical and effective. The program successfully detected small RCCs, demonstrating the value of US in early cancer detection.
Area of Science:
- Urology
- Diagnostic Imaging
- Public Health
Background:
- Increasing incidental detection of small renal cell carcinoma (RCC) by ultrasonography (US).
- Need to assess feasibility and effectiveness of systematic RCC screening.
Purpose of the Study:
- To evaluate the practicability and efficacy of systematic renal cell carcinoma (RCC) screening using ultrasonography (US).
Main Methods:
- A 2-year screening program for RCC in adults aged 40+ in two German cities.
- Recruitment of general practitioners, internists, and urologists for renal US.
- Offered cost-free renal US in year 1 and re-examination in year 2, with reference US for equivocal findings.
Main Results:
- 9959 volunteers participated; 79% returned for follow-up.
- Thirteen renal masses identified (0.1%), including nine RCCs.
- Program sensitivity was 82%; predictive value for positive findings was 50%.
Conclusions:
- The screening program was well-accepted by physicians and the public.
- Systematic US screening is effective for detecting RCC, especially with reference US for equivocal findings.
- Reduces need for further advanced imaging like CT or MRI.