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A randomised double-blind evaluation of adenosine as adjunct to sufentanil in spinal labour analgesia
K Rane1, A Sollevi, M Segerdahl
1Department of Anaesthesia and Intensive Care, Danderyd Hospital, Danderyd, Sweden. kerstin.rane@ane.ds.sll.se
Background:
Intrathecal injection of sufentanil offers labour pain relief of short duration. This double-blind randomised study evaluates if the combination of adenosine to sufentanil could give relevant prolongation (40%) of the duration of sufentanil spinal analgesia.
Methods:
Twenty-five healthy parturients requesting labour analgesia were included. Patients received 10 micro g of sufentanil + 500 micro g of adenosine or 10 micro g of sufentanil intrathecally. Pain intensity and duration of pain relief were assessed.
Results:
Pain relief was equal between groups. Duration of analgesia was not increased by adenosine + sufentanil, 99 +/- 54 min, vs. sufentanil, 89 +/- 56 min.
Conclusion:
Adding 500 micro g of adenosine to 10 micro g of sufentanil could not provide any prolongation of labour pain relief.