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Chain-branched acyclic phenethylthiocarbamates as vanilloid receptor antagonists
JungWha Yoon1, HyeYoung Choi, Hyun Joo Lee
1College of Pharmacy, Sookmyung Women's University, 53-12 Chungpa-dong, Yongsan-ku, Seoul 140-742, South Korea.
Bioorganic & Medicinal Chemistry Letters
|April 18, 2003
Abstract:
A series of acyclic phenethylthiocarbamate derivatives have been synthesized, and their antagonist effect against vanilloid receptor tested. Chain branching led to a significant change in antagonist activity of the parent molecule. Ethyl-branched 1e showed a 6.3 microM of IC(50) value in 45Ca(2+)-influx assay.