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Macrocyclic inhibitors of the bacterial cell wall biosynthesis enzyme MurD
James R Horton1, Julieanne M Bostock, Ian Chopra
1Departments of Chemistry, University of Leeds, Leeds LS2 9JT, UK.
Bioorganic & Medicinal Chemistry Letters
|April 18, 2003
Abstract:
Computer-based molecular design has been used to produce a series of new macrocyclic systems targeted against the bacterial cell wall biosynthetic enzyme MurD. Following their preparation, which involved a novel metathesis-based cyclisation as the key step, these systems were found to show good inhibition when assayed against the MurD enzyme.