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Published on: June 29, 2013
Prediction of intrauterine growth restriction with customised estimated fetal weight centiles
Philip Owen1, Jo Ogah, Lucas M Bachmann
1North Glasgow NHS University Trust, UK.
Insights
Third trimester customized estimated fetal weight centiles moderately identify infants with intrauterine growth restriction (IUGR). However, fetal growth velocity is more accurate for predicting low ponderal index in newborns.
Area of Science:
- Obstetrics and Gynecology
- Fetal Medicine
- Neonatalogy
Background:
- Intrauterine growth restriction (IUGR) is a significant concern in high-risk pregnancies.
- Accurate prediction of IUGR is crucial for timely intervention and improved neonatal outcomes.
- Third-trimester fetal biometry plays a key role in assessing fetal growth and well-being.
Purpose of the Study:
- To evaluate the predictive value of third-trimester customized estimated fetal weight (cEFW) centiles for identifying infants with anthropometric features of IUGR.
- To compare the performance of cEFW centiles against fetal growth velocity (FGV) in predicting IUGR.
Main Methods:
- A prospective, observational study involving 274 women with low-risk pregnancies.
- cEFW centiles were calculated adjusting for gestational age, birth order, gender, maternal height, weight, and ethnicity.
- FGV was determined using the increment in fetal abdominal area over a 28-day interval, expressed as a Z-score.
- IUGR was defined by neonatal anthropometric measures: subscapular/triceps skinfold thickness <10th centile, ponderal index <25th centile, or mid-arm circumference to occipito-frontal circumference ratio <-1 SD.
Main Results:
- cEFW centiles <5th and <10th showed moderate likelihood ratios for predicting IUGR based on skinfold thickness and ponderal index.
- Likelihood ratios for cEFW <5th were 4.9-6.8, and for cEFW <10th were 4.1-7.1 across different IUGR anthropometric measures.
- Fetal abdominal area growth velocity demonstrated a higher predictive value than cEFW centiles for a low ponderal index (P = 0.04).
Conclusions:
- Third-trimester customized estimated fetal weight centiles offer moderate utility in identifying infants with IUGR.
- Fetal growth velocity calculations provide a more accurate prediction of low ponderal index compared to cEFW centiles.
- Both methods contribute to the assessment of fetal growth, with FGV showing an advantage in specific IUGR predictions.
Objectives:
1. To determine the value of third trimester customized estimated fetal weight centile ranking in the prediction of infants born with anthropometric features of intrauterine growth restriction (IUGR). 2. To compare the performance of customized centiles with fetal growth velocity in the prediction of IUGR.
Design:
Prospective, observational study.
Setting:
Department of Obstetric Ultrasound.
Population:
Two hundred and seventy-four women with low risk pregnancies who were participants in a previously published longitudinal study of fetal biometry.
Methods:
Third trimester estimated fetal weight customized centiles were obtained after adjustment for gestational age at the time of ultrasound, birth order and gender, maternal weight, height and ethnic origin. Fetal growth velocity was calculated using the increment in the fetal abdominal area over a mean 28-day interval. Fetal abdominal area growth velocity was expressed as a standard deviation (Z score). Three neonatal anthropometric measures were used to define IUGR: subscapular or triceps skinfold thickness <10th centile, ponderal index <25th centile, mid-arm circumference to occipito-frontal circumference <-1 SD. The ability of estimated fetal weight customized centiles <5th centile and <10th centile to identify growth restriction was determined by calculating likelihood ratios.
Main Outcome Measure:
Likelihood ratios for the prediction of neonatal anthropometric features of IUGR.
Results:
Two hundred and fifty-eight infants had an estimated fetal weight customized centile calculated and one or more anthropometric measurements. The mean customized estimated fetal weight centile for cases with and without a low skinfold thickness were 16.4 vs 41.7 (P < 0.01); the mean values of customized estimated fetal weight centile for cases with and without ponderal index <25th centile were 22.8 vs 42.7 (P < 0.01); mean estimated fetal weight customized centiles for cases with and without mid-arm circumference to occipito-frontal circumference <-1 SD were 26.3 vs 40.5 (P > 0.05). A customized estimated fetal weight centile of 5 or less had likelihood ratios (95% CI) of 4.9 (2.7-6.3), 6.8 (4.5-10.6) and 6.3 (3.7-14) for skinfold thickness <10th centile, ponderal index <25th centile and mid-arm circumference to occipito-frontal circumference <-1 SD, respectively. An estimated fetal weight customized centile of 10 or less had likelihood ratios of 4.5 (2.6-8.6), 4.1 (2.5-7.2) and 7.1 (3.5-24) for skinfold thickness <10th centile, ponderal index <25th centile and mid-arm circumference to occipito-frontal circumference <-1 SD, respectively. In the prediction of a ponderal index <25th centile, the fetal abdominal area velocity likelihood ratio for a positive test is higher than the likelihood ratio for the 10th estimated fetal weight customized centile (P = 0.04) but is not significantly higher for the other outcomes. The fetal abdominal area velocity likelihood ratio is not significantly higher than the likelihood ratios for the fifth estimated fetal weight customized centile for any of the three outcomes.
Conclusion:
Customized estimated fetal weight centiles in the late third trimester are moderately useful in the identification of infants with IUGR but are less accurate than calculated growth velocity in the prediction of an infant with a low ponderal index.
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