Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Simultaneous electroanalysis of dopamine and ascorbic acid using poly (N,N-dimethylaniline)-modified electrodes.

Protiva Rani Roy1, Takeyoshi Okajima, Takeo Ohsaka

  • 1Department of Electronic Chemistry, Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama, Japan.

Bioelectrochemistry (Amsterdam, Netherlands)
|April 18, 2003
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synergistic Defect Engineering and Interface Stability of Activated Carbon Nanotubes Enabling Ultralong Lifespan All-Solid-State Lithium-Sulfur Batteries.

ACS applied materials & interfaces·2023
Same author

Multichalcogen-Integrated Cathodes for Novel Lithium-Chalcogenide Batteries in Ether and Ester Electrolytes.

ACS applied materials & interfaces·2022
Same author

Designing conductive networks of hybrid carbon enables stable and long-lifespan cotton-fiber-based lithium-sulfur batteries.

RSC advances·2022
Same author

Dilute Electrolyte to Mitigate Capacity Decay and Voltage Fading of Co-Free Li-Rich Cathode for Next-Generation Li-Ion Batteries.

ACS applied materials & interfaces·2022
Same author

High-Efficiency Electrolyte for Li-Rich Cathode Materials Achieving Enhanced Cycle Stability and Suppressed Voltage Fading Capable of Practical Applications on a Li-Ion Battery.

ACS applied materials & interfaces·2020
Same author

Self-assembled nitrogen-doped fullerenes and their catalysis for fuel cell and rechargeable metal-air battery applications.

Nanoscale·2017

A novel N,N-dimethylaniline polymer film on a glassy carbon electrode effectively detects dopamine (DA) amidst ascorbic acid (AA). This modified electrode offers enhanced sensitivity and selectivity for DA detection, crucial for biological applications.

Area of Science:

  • Electrochemistry
  • Materials Science
  • Analytical Chemistry

Background:

  • Electrochemical detection of dopamine (DA) is often hindered by interference from ascorbic acid (AA).
  • Developing selective and sensitive electrochemical sensors is crucial for accurate biomolecule analysis.

Purpose of the Study:

  • To modify a glassy carbon (GC) electrode with an electropolymerized N,N-dimethylaniline (PDMA) film for enhanced electrochemical detection of dopamine (DA).
  • To investigate the influence of the PDMA film's properties, such as charge and hydrophobicity, on the selective detection of DA in the presence of ascorbic acid (AA).

Main Methods:

  • Electropolymerization of N,N-dimethylaniline (DMA) onto a glassy carbon (GC) electrode to form a positively charged, hydrophobic polymer film (PDMA).
  • Cyclic voltammetry (CV) and square wave voltammetry (SWV) were employed to study the electrochemical behavior of dopamine (DA) and ascorbic acid (AA) at both bare and PDMA-modified GC electrodes.

Related Experiment Videos

  • Varied monomer concentrations (0.2, 0.1, and 0.05 M DMA) were used to control film thickness and properties.

    • Main Results:

    • The PDMA film exhibited favorable ionic interactions, shifting AA oxidation potential negatively and DA oxidation potential positively due to electrostatic effects.
    • Hydrophobic interactions within the PDMA film facilitated DA incorporation and influenced the voltammetric responses of both DA and AA.
    • The PDMA-modified electrode successfully separated DA and AA oxidation potentials by approximately 300 mV, enabling sensitive detection of 0.2 microM DA in the presence of a 1000-fold excess of AA.
    • Fouling effects and catalytic oxidation of AA by oxidized DA were eliminated, unlike with the bare electrode.

    Conclusions:

    • The PDMA film-coated GC electrode provides a robust platform for the selective and sensitive electrochemical detection of dopamine.
    • The combined electrostatic and hydrophobic properties of the PDMA film are key to its ability to differentiate and detect DA in complex biological matrices.
    • This approach offers a promising solution for overcoming interference issues in dopamine sensing for physiological level analysis.