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Endothelial nitric oxide synthase polymorphism in preeclampsia.
Tanja Häkli1, Eeva-Liisa Romppanen, Mikko Hiltunen
1Department of Obstetrics and Gynecology, Kuopio University and University Hospital, Kuopio, Finland.
Journal of the Society for Gynecologic Investigation
|April 18, 2003
Summary
Genetic variations in the endothelial nitric oxide synthase (eNOS) gene did not significantly increase preeclampsia risk in this Finnish cohort. Further research into other eNOS gene polymorphisms is warranted to understand their role in preeclampsia development.
Area of Science:
- Genetics
- Obstetrics
- Cardiovascular Biology
Background:
- Preeclampsia is a serious pregnancy complication.
- Endothelial nitric oxide synthase (eNOS) plays a role in vascular health.
- Genetic factors may influence preeclampsia susceptibility.
Purpose of the Study:
- To investigate if genetic variations in the eNOS gene affect preeclampsia risk.
- To examine the association between the eNOS Glu298Asp polymorphism and preeclampsia.
Main Methods:
- Genotyping of 132 preeclamptic and 113 control women for the eNOS Glu298Asp polymorphism.
- Chi-squared analysis to compare genotype and allele frequencies between groups.
Main Results:
- No significant difference in eNOS Glu298Asp allele or genotype frequencies between preeclamptic and control groups.
- The variant G allele frequency was 74.6% in preeclamptics vs. 67.7% in controls (P=0.091).
Conclusions:
- The eNOS Glu298Asp polymorphism does not appear to be a major risk factor for preeclampsia in this population.
- Other polymorphisms within the eNOS gene might contribute to preeclampsia risk.