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Integrins in the development, function and dysfunction of the nervous system.

Dennis O Clegg1, Kevin L Wingerd, Sherry T Hikita

  • 1Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, California 93106, USA. clegg@lifesci.ucsb.edu

Frontiers in Bioscience : a Journal and Virtual Library
|April 18, 2003
PubMed
Summary

Integrins are crucial cell receptors involved in neural development, adult brain function, and nervous system diseases. Future research will explore specific integrin roles and their ligands in the nervous system.

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Integrin receptors mediate cell-cell and cell-extracellular matrix (ECM) interactions.
  • Integrins play roles in axon extension, cell adhesion, and migration in the central nervous system (CNS).

Purpose of the Study:

  • To summarize recent findings on integrin functions throughout neural development and in the adult nervous system.
  • To highlight the involvement of specific integrins in neurological diseases.
  • To identify future research directions.

Main Methods:

  • Literature review and summary of recent studies on integrin function in the nervous system.

Main Results:

  • Integrins are vital in neural development, from neuroblast migration to synapse formation.

Related Experiment Videos

  • Beta-1 and alpha-v integrins are widely expressed on developing neurons and are regulated.
  • Integrins are implicated in synaptic plasticity, learning, memory, and nervous system diseases involving leukocytes and glial cells.

    • Conclusions:

    • Integrins are essential for various stages of neural development and adult brain function.
    • Specific integrin heterodimers and their ligands in the nervous system require further investigation.