Related Experiment Video
Updated: Jul 16, 2026

A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation
Published on: March 15, 2018
Osteoclasts, pro-inflammatory cytokines, RANK-L and bone remodeling in rheumatoid arthritis
Charles Kaplan1, Alison Finnegan
1Department of Immunology/Microbiology, Rush-Presbyterian-St. Luke's Medical Cente, Chicago, IL 60612, USA. Charles_Kaplan@rush.edu
Abstract:
Inflammatory joint diseases such as rheumatoid arthritis tend to destroy joint cartilage and bone matrices. Since bone resorption is a common characteristic of rheumatoid arthritis, one of the cell types thought to play a vital role in the destruction of these matrices are the osteoclasts. Osteoclasts and osteoclastogenic factors such as inflammatory cytokines and RANK-L are present within inflamed joints, and osteoclastic bone resorptive activities are also displayed, further suggesting the possibility that osteoclasts are responsible for the joint cartilage and bone matrix damage observed in this joint disease.
Related Concept Videos
Bone Remodeling
Osteoclasts in Bone Remodeling
The JAK-STAT Signaling Pathway
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Chronic Inflammation: Introduction

