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Related Experiment Videos

High density lipoprotein structure.

Sissel Lund-Katz1, Lijuan Liu, Stephen T Thuahnai

  • 1GI/Nutrition Division, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4318, USA.

Frontiers in Bioscience : a Journal and Virtual Library
|April 18, 2003
PubMed
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High-density lipoprotein (HDL) structure is key to its antiatherogenic functions. This review details HDL subclasses, apolipoprotein A-I interactions, and dynamic remodeling processes influencing particle structure.

Area of Science:

  • Lipid metabolism and cardiovascular science.

Background:

  • High-density lipoprotein (HDL) particles have crucial antiatherogenic properties.
  • Understanding HDL's structure is essential for elucidating its protective mechanisms against atherosclerosis.

Purpose of the Study:

  • To review the current knowledge of HDL particle structure.
  • To compare different HDL subclasses based on their lipid and protein content.
  • To discuss the dynamic remodeling of HDL in vivo.

Main Methods:

  • Review of existing literature on HDL structure and function.
  • Comparison of lipid and protein compositions across various HDL subclasses.
  • Evaluation of low-resolution structural models for discoidal and spherical HDL particles.

Main Results:

Related Experiment Videos

  • HDL structure is influenced by apolipoprotein A-I's lipid-binding capacity and amphipathic alpha-helical domains.
  • HDL particles exhibit plasticity and are dynamically remodeled by enzymes and receptors.
  • Interactions with proteins like LCAT, CETP, SR-BI, and ABCA1 modulate HDL structure.

Conclusions:

  • Detailed knowledge of HDL structure, including its subclasses and dynamic remodeling, is vital for understanding its antiatherogenic roles.
  • Apolipoprotein A-I plays a central role in mediating HDL structure and function.
  • In vivo remodeling significantly impacts HDL particle composition and properties.