Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Androgens and coronary artery disease.

Fredrick C W Wu1, Arnold von Eckardstein

  • 1Department of Endocrinology, Manchester Royal Infirmary, University of Manchester, Manchester M13 9WL, United Kingdom. fredrick.wu@man.ac.uk

Endocrine Reviews
|April 18, 2003
PubMed
Summary

Testosterone (T) levels show no confirmed link to coronary events. While low T is seen in men with heart disease, its role in atherosclerosis is unclear due to complex factors and mixed research findings.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The COPI coatomer influences LDL receptor activity, hepatic lipid storage, and apoB secretion.

bioRxiv : the preprint server for biology·2026
Same author

HDL Are Host Defense Lipoproteins.

Circulation research·2026
Same author

Association between aldehyde dehydrogenase 4 family member A1 plasma concentrations and atherosclerotic disease in patients with ischemic stroke: Results from the prospective multicenter BIOSIGNAL study.

Clinica chimica acta; international journal of clinical chemistry·2026
Same author

Multi-biomarker approach for predicting cardiac magnetic resonance parameters at 30 days after ST-segment elevation myocardial infarction.

International journal of cardiology. Heart & vasculature·2026
Same author

Genetic Cascade Screening for Familial Hypercholesterolemia: A Randomized Clinical Trial.

JAMA network open·2026
Same author

Bilirubin interference in creatinine assays: cross-sectional analysis of the impact on the MELD score and CKD staging using Jaffe vs enzymatic methods.

Swiss medical weekly·2026

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Atherosclerosis Research

Background:

  • Endogenous testosterone (T) levels lack confirmed independent association with coronary events in large prospective studies.
  • Cross-sectional data suggest a link between low T and coronary heart disease in men.
  • Hypoandrogenemia in men and hyperandrogenemia in women are associated with metabolic risk factors like obesity and insulin resistance.

Purpose of the Study:

  • To clarify the role of endogenous and exogenous testosterone in atherosclerosis.
  • To evaluate the cardiovascular effects of testosterone therapy.

Main Methods:

  • Review of prospective studies, cross-sectional data, and animal experiments on testosterone and cardiovascular health.
  • Analysis of observational studies on dehydroepiandrosterone sulfate and coronary artery disease.
  • Examination of preliminary data on exogenous testosterone's effects on cardiovascular outcomes.

Main Results:

  • Inconsistent findings regarding endogenous testosterone's direct role in atherosclerosis.
  • Exogenous androgens demonstrate mixed effects on cardiovascular risk factors, with both beneficial and deleterious impacts observed.
  • Testosterone's effects on vascular reactivity and macrophage function are concentration-dependent and context-specific.

Conclusions:

  • Current evidence does not support a significant net effect of testosterone on atherosclerosis.
  • Therapeutic testosterone use in men does not require restriction due to cardiovascular concerns based on available data.
  • Uncontrolled use of testosterone or dehydroepiandrosterone for cardiovascular prevention or treatment is not justified.

Related Experiment Videos