Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell selection in vivo in normal/aneuploid chromosome abnormalities.

J Nielsen

    Human Genetics
    |May 19, 1976
    PubMed
    Summary

    Mixoploid children often show a normalization of chromosome constitution over time. Follow-up studies reveal that many children with mixoploid abnormalities at birth may have normal lymphocyte cultures as adults.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Population balance models of autonomous microbial oscillations.

    Journal of biotechnology·1995
    Same author

    Induction and repression of alpha-amylase production in batch and continuous cultures of Aspergillus oryzae.

    Microbiology (Reading, England)·1995
    Same author

    Continuous cultivation of Penicillium chrysogenum. Growth on glucose and penicillin production.

    Journal of biotechnology·1995
    Same author

    Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway.

    Nature·1995
    Same author

    Mechanical and electromyographic analysis of reciprocal inhibition at the human ankle joint.

    Journal of neurophysiology·1995
    Same author

    Evidence favouring different descending pathways to soleus motoneurones activated by magnetic brain stimulation in man.

    The Journal of physiology·1995

    Area of Science:

    • Genetics
    • Developmental Biology
    • Pediatrics

    Background:

    • Mixoploidy, a condition involving multiple cell lines with different chromosome numbers, can occur in newborns.
    • Understanding the long-term cytogenetic profile of these individuals is crucial for clinical management.

    Purpose of the Study:

    • To investigate the cytogenetic follow-up of children diagnosed with mixoploidy at birth.
    • To assess the stability and potential normalization of chromosomal constitution in these individuals over time.

    Main Methods:

    • Cytogenetic analysis of lymphocyte cultures from 9 mixoploid children.
    • Longitudinal examination of chromosome constitution from birth to follow-up.

    Main Results:

    • Four out of nine children showed a significant increase in the normal chromosome cell line frequency.
    • One child exhibited a significant decrease in the normal cell line.
    • In three cases, the normal chromosome frequency increased from 32-68% to over 93%.

    Conclusions:

    • Mixoploid chromosome abnormalities in newborns can exhibit significant normalization in lymphocyte cultures during childhood.
    • This normalization may occur despite the presence of clinical signs associated with the initial chromosomal aberration.
    • Further research is needed to understand the implications for long-term health outcomes.

    Related Experiment Videos