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Bone metastases from osteosarcoma.

M San-Julian1, P Diaz-de-Rada, E Noain

  • 1Department of Orthopaedics, University Clinic, University of Navarra, 31080-Pamplona, Spain. Msjulian@unav.es

International Orthopaedics
|April 18, 2003
PubMed
Summary
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Osteosarcoma bony metastases are rare. Surgical resection of solitary metastases after neoadjuvant chemotherapy offers a curative option, while multiple metastases have a poor prognosis.

Area of Science:

  • Oncology
  • Orthopedic Surgery
  • Cancer Metastasis

Background:

  • Bony metastases in osteosarcoma are uncommon and typically occur late.
  • This study investigates outcomes for patients with osteosarcoma and bone metastases.

Purpose of the Study:

  • To evaluate the efficacy of treatment strategies for osteosarcoma with bony metastases.
  • To determine prognostic factors for patients with osteosarcoma bone metastases.

Main Methods:

  • Retrospective review of eight osteosarcoma patients with bony metastases.
  • Analysis of treatment approaches: neoadjuvant chemotherapy and surgery for solitary metastases; palliative care for multiple metastases.

Main Results:

  • Three of four patients with solitary metastases survived with no evidence of disease after 5-8 years post-surgery.

Related Experiment Videos

  • Histology and response to neoadjuvant chemotherapy were similar in primary and metastatic lesions, indicating predictive value.
  • None of the four patients with multiple metastases survived.

    • Conclusions:

    • Resection of solitary bony metastases from osteosarcoma following neoadjuvant chemotherapy can be curative.
    • Treatment of multiple osteosarcoma metastases with palliative measures yields a poor prognosis.
    • Response to neoadjuvant chemotherapy is a key predictor of outcome in osteosarcoma with bone metastases.